What problems did the colonists face in Roanoke?

It's never easy to establish a colony in a far-off, distant land, and the Roanoke colonists certainly had more than their fair share of problems. For one thing, there were chronic shortages of food. Many of the colonists had been lured to the New World with the promise of abundant food supplies once they arrived. But in reality, the soil was completely different from what the settlers were used to, and they found themselves unable to cultivate it. Fairly soon, it was established that the colony needed to import substantial quantities of food from England if it were to survive. The colonists also depended to a considerable extent on food supplied to them by the Algonquin tribe. The Algonquin also taught the English settlers how to farm the native land and fish in its waters.
Despite the assistance of the Algonquin, relations between them and the colonists turned sour, not least because the white settlers wouldn't accept the indigenous people—people they regarded as little more than savages and heathens—as their equals. The ensuing animosity ensured that it became increasingly difficult to establish a viable, long-term settlement. Antagonism between the native population and the English settlers, combined with chronic food shortages, led to the inevitable failure of the Roanoke colony. Nonetheless, lessons had been learned, and future colonialists would try to avoid the mistakes made by their predecessors.