How different were the thirteen colonies from each other?

The thirteen colonies differed with respect to when, how, and why they were founded as well as their natural resources. The Middle Colonies were some of the most productive of crops like grain, which earned them the nickname of the "breadbasket" of the colonies, and they were also home to many Quakers. The natural resources in these Middle Colonies included lumber, wheat, and corn.
The New England Colonies, which were the northernmost colonies, were founded by Puritan separatists known as Pilgrims. Their natural resources included fish and rum. The New England colonies produced few cash crops, as the growing season was very short in the comparatively cold climate, and the soil was rocky for farming.
The Southern Colonies (Maryland, the Carolinas, Virginia, and Georgia) comprised many Anglicans and Catholics as well as Protestants. As a group, they were diverse, owing to the size of their land (which is why North and South Carolina were eventually divided). Farming was essential to this region, which had many plantations equipped with indentured servants and eventually slaves, and cotton was the major crop.