Oxygen generally combines quickly and reversibly with hemoglobin. However, environmental changes can change oxygen molecules’ affinity for hemoglobin. The “Bohr effect” is the lower affinity of hemoglobin for oxygen; this occurs because of decreases in blood pH along with increases in the partial pressure of carbon dioxide. Lower affinity then enhances the unloading of oxygen into tissues in order to meet the tissues’ demand for oxygen. The increase in hydrogen ion concentration, which stems from increased carbon dioxide (owing to increased metabolic activity), then leads to a decrease in pH. The combined effects are what cause the decrease in the affinity of hemoglobin for oxygen.
The Bohr effect takes its name from an observation that Danish physiologist Christian Bohr made in 1904.
https://www.encyclopedia.com/plants-and-animals/zoology-and-veterinary-medicine/zoology-general/bohr-effect
https://www.ncbi.nlm.nih.gov/books/NBK526028/
No comments:
Post a Comment